CBD Therapeutic Benefits

Disease

Effects

Alzheimer's disease

Antinflammatory, antioxidant, antiapoptotic in in vitro and in vivo models
of Aβ-evoked neuroinflammatory and neurodegenerative responses.

Parkinson's disease

Attenuation of the dopaminergic impairment in vivo; neuroprotection; improvement of psychiatric rating and reduction of agitation, nightmare
and aggressive behaviour in patients.

Multiple sclerosis

Improved signs of EAE in mice, antinflammatory and immunomodulatory
properties.

Huntington's
disease

Neuroprotective and antioxidant in mice transgenic models; no significant
clinically important differences in patients.

Hypoxia-ischemia
injury

Short term neuroprotective effects; inhibition of excitotoxicity, oxidative
stress and inflammation in vitro and in rodent models.

Pain

Analgesic effect in patients with neuropathic pain resistant to other
treatments.

Psychosis

Attenuation of the behavioural and glial changes in animal models of
schizophrenia; anti-psychotic properties on ketamine-induced symptoms

Anxiety

Reduction of muscular tension, restlessness, fatigue, problems in concentration, improvement of social interactions in rodent models of
anxiety and stress; reduced social anxiety in patients.

Depression

Anti-depressant effect in genetic rodent model of depression.

Cancer

Antiproliferative and anti-invasive actions in a large range of cancer types;
induction of autophagy-mediated cancer cell death; chemopreventive effects.

Nausea

Suppression of nausea and conditioned gaping in rats

Inflammatory
diseases

Antinflammatory properties in several in vitro and in vivo models;
inhibition of inflammatory cytokines and pathways.

Rheumatoid
arthritis

Inhibition of TNF-α in an animal model

Infection

Activity against methicillin-resistant Staphylococcus aureus

Inflammatory bowel and Crohn's
diseases

Inhibition of macrophage recruitment and TNF-α secretion in vivo and ex vivo; reduction in disease activity index in Crohn's patients.

Cardiovascular
diseases

Reduced infarct size through anti-oxidant and anti-inflammatory
properties in vitro and in vivo.

Diabetic
complications

Attenuation of fibrosis and myocardial dysfunction